Thiol redox homeostasis in neurodegenerative disease
نویسندگان
چکیده
منابع مشابه
Thiol redox homeostasis in neurodegenerative disease
This review provides an overview of the biochemistry of thiol redox couples and the significance of thiol redox homeostasis in neurodegenerative disease. The discussion is centred on cysteine/cystine redox balance, the significance of the xc(-) cystine-glutamate exchanger and the association between protein thiol redox balance and neurodegeneration, with particular reference to Alzheimer's dise...
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1 Instituto de Bioquímica Vegetal y Fotosíntesis, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas, Sevilla, Spain 2 INRES Chemical Signalling, University of Bonn, Bonn, Germany 3 Laboratoire Génome et Développement des Plantes, Université Perpignan Via Domitia, Perpignan, France 4 Laboratoire Génome et Développement des Plantes, CNRS, Perpignan, France 5 Faculté des Scie...
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AIM To determine dynamic thiol/disulphide homeostasis in celiac disease and to examine the associate with celiac autoantibodies and gluten-free diet. METHODS Seventy three patients with celiac disease and 73 healthy volunteers were enrolled in the study. In both groups, thiol/disulphide homeostasis was examined with a new colorimetric method recently developed by Erel and Neselioglu. RESULT...
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Much attention has been devoted to neurodegenerative diseases involving redox processes. This review comprises an update involving redox processes reported in the considerable literature in recent years. The mechanism involves reactive oxygen species and oxidative stress, usually in the brain. There are many examples including Parkinson's, Huntington's, Alzheimer's, prions, Down's syndrome, ata...
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A new type of resorufin-based dual-functional fluorescent probe whose fluorescence emission features are sensitive to thiol compounds and redox homeostasis was developed. Thiols-triggered nucleophilic substitution of the probes converts the nonfluorescent probe to the highly fluorescent resorufin moiety; the released resorufin not only enables fluorescence signaling specific for thiol compounds...
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ژورنال
عنوان ژورنال: Redox Biology
سال: 2015
ISSN: 2213-2317
DOI: 10.1016/j.redox.2015.04.004